Polynucleotides: A Revolutionary Approach to Skin Regeneration Treatment in London

Written by Dr. Chike Emeagi MBBS MBA - Medical Director, Hampstead Aesthetics

What are Polynucleotides?

Polynucleotides are bio-stimulators derived from fragments of salmon DNA, renowned for their remarkable ability to rejuvenate ageing skin. By stimulating elastin and collagen production, these powerful molecules deliver a surge of hydration, significantly improving skin texture and elasticity.

Working at a cellular level, polynucleotides activate specific receptors on fibroblast cells within the tissues, prompting a natural healing response. This process results in visible skin regeneration, making polynucleotides one of the premium products available for skin rejuvenation. 

Whether you’re looking to combat the signs of ageing skin or enhance overall skin health, polynucleotide treatments offer a revolutionary approach to achieving youthful, radiant skin.

What is Polynucleotide Treatment?

Polynucleotide (PN) treatment is an innovative bioregenerative therapy designed to stimulate collagen production, enhance skin repair, and improve tissue regeneration. Polynucleotides are naturally occurring nucleic acid molecules that play a critical role in cellular repair, DNA synthesis, and anti-inflammatory processes. This cutting-edge treatment is widely used in aesthetic medicine, dermatology, and regenerative therapy for skin rejuvenation, wound healing, and anti-aging benefits.

Unlike traditional dermal fillers, polynucleotides are administered through an injectable treatment that works at a cellular level to improve skin hydration, elasticity, and structure by activating fibroblast proliferation, reducing oxidative stress, and improving extracellular matrix remodeling.

How Does Polynucleotide Treatment Work?

Polynucleotide therapy functions through several key mechanisms:

1. Cellular Regeneration: Polynucleotides promote fibroblast proliferation and differentiation, leading to enhanced collagen and elastin production for firmer, younger-looking skin. Additionally, polynucleotides are effective in improving skin elasticity by promoting collagen production.

   
   

2. Deep Skin Hydration: Polynucleotides are hygroscopic molecules, meaning they attract and retain moisture, significantly improving skin hydration and elasticity.

3. Anti-Inflammatory Action: Polynucleotides reduce oxidative stress and inflammation, making them ideal for sensitive skin, rosacea, and post-laser recovery.

4. Tissue Repair and Healing: By stimulating angiogenesis (new blood vessel formation), polynucleotides accelerate skin repair and improve wound healing.

5. DNA Repair and Antioxidant Protection: Polynucleotides protect skin cells from environmental damage, ensuring long-term skin health and resilience.

   
   

Scientific Evidence Supporting Polynucleotide Therapy and Collagen Production

📌 A study published in the Journal of Cosmetic Dermatology (2022) found that polynucleotide injections significantly improved skin elasticity, hydration, and collagen density over a 12-week period.

📌 Research in the International Journal of Molecular Sciences (2021) confirmed that polynucleotides reduce oxidative stress and inflammation, supporting long-term anti-aging benefits.

📌 A clinical trial published in the Journal of Regenerative Medicine (2023) demonstrated that patients receiving polynucleotide therapy for skin rejuvenation experienced significant improvements in fine lines, texture, and skin thickness.

Benefits of Polynucleotide Treatment

✅ Deep hydration and skin plumping

✅ Stimulates natural collagen and elastin production

✅ Reduces fine lines, wrinkles, and sagging skin

✅ Improves skin elasticity and firmness

✅ Supports skin repair and wound healing

✅ Reduces redness, oxidative stress, and inflammation

✅ Safe for all skin types with minimal downtime

✅ Can be used in combination with other aesthetic treatments

✅ Helps in maintaining skin elasticity over time

Who is Polynucleotide Therapy Suitable For?

Polynucleotide injections are ideal for individuals who:

• Want to improve skin texture, elasticity, and hydration

• Have fine lines, wrinkles, or skin laxity

• Suffer from acne scars or sun damage

• Want a non-surgical, biostimulatory alternative to traditional fillers

• Are looking for a regenerative approach to anti-aging treatments

• Are looking for skin boosters to enhance skin quality

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Treatment Areas

✔ Face – Improves skin firmness, hydration, and radiance. Polynucleotide treatments can also improve skin elasticity in the facial area.

✔ Neck & Décolletage – Firms and tightens sagging skin

✔ Under-Eyes – Reduces fine lines, dark circles, and hollows

✔ Hands – Rejuvenates and plumps the skin

✔ Scalp – Supports hair follicle regeneration and improves hair density

✔ Post-Laser & Surgical Recovery – Enhances skin healing and reduces inflammation

Under Eye Treatment

The delicate area under the eyes often shows early signs of ageing, such as puffiness, fine lines, and hollow tear troughs. Polynucleotide injections provide an effective solution by hydrating and plumping up the tissue, reducing puffiness and smoothing out lines. This treatment is particularly beneficial for those concerned with tear troughs and hollow areas under the eyes. Additionally, polynucleotide treatment can be combined with laser skin treatments to address acne scars and improve conditions like rosacea, offering a comprehensive approach to under-eye rejuvenation and overall skin health.

What to Expect During Polynucleotide Treatment

🔹 Consultation: A thorough skin assessment is performed to create a personalized treatment plan.

🔹 Injection Process: Polynucleotides are delivered via microinjections or mesotherapy techniques as part of injectable treatments into the targeted areas.

🔹 Treatment Duration: Sessions typically last 30-45 minutes.

🔹 Post-Treatment Care: Mild redness or swelling may occur but subsides within a few hours.

How Many Polynucleotide Sessions Are Needed?

For best results, a course of three to four sessions spaced two to four weeks apart is recommended. Maintenance sessions every 6-12 months help sustain skin improvements and long-term collagen stimulation.

Treatment Sessions and Aftercare

For optimal results, a short course of polynucleotide treatment sessions spaced a few weeks apart is recommended. Post-treatment, it is normal to experience mild swelling or bruising, along with redness or tiny bumps at the injection sites. Fortunately, there is very little downtime, allowing most individuals to resume their routine activities immediately. Following the aftercare steps provided by your practitioner is crucial to ensure the best results and minimize any potential side effects. This includes avoiding direct sunlight, refraining from strenuous activities, and keeping the treated area clean and moisturized.

Polynucleotide Face Treatment

FAQs About Polynucleotide Therapy

1. Is Polynucleotide Therapy Safe?

Yes! Polynucleotide therapy is clinically tested, FDA-approved, and widely used in regenerative medicine. The treatment is derived from biocompatible, purified DNA molecules, ensuring minimal risk of allergic reactions, inflammation, or adverse effects. Polynucleotides support natural cellular repair, reducing oxidative stress while promoting skin rejuvenation.

2. How Soon Will I See Results from Polynucleotide Treatment?

Most patients notice improved skin hydration and glow within the first week, while full collagen remodeling, skin elasticity enhancement, and anti-aging effects develop over three to six months.

3. Can Polynucleotides Be Combined with Other Treatments?

Yes! Polynucleotide therapy works synergistically with microneedling, PRP (Platelet-Rich Plasma), fractional laser treatments, and radiofrequency skin tightening to further enhance skin regeneration, hydration, and collagen stimulation.

4. How Do Polynucleotides Compare to Traditional Dermal Fillers?

Unlike traditional hyaluronic acid fillers for tear trough treatment, which add immediate volume, polynucleotides stimulate natural collagen and elastin production over time, offering long-term structural improvement and enhanced skin quality.

5. How Long Do Polynucleotide Treatment Results Last?

Results typically last six to twelve months, depending on individual skin health, age, lifestyle habits, and maintenance sessions. Regular follow-up treatments can prolong skin rejuvenation benefits.

6. Who Should Avoid Polynucleotide Therapy?

Polynucleotide therapy is suitable for most individuals, but those who are pregnant, breastfeeding, have active skin infections, or autoimmune conditions should consult with a medical professional before undergoing treatment.

7. Is There Downtime After Polynucleotide Treatment?

Most patients experience minimal downtime, with mild redness, swelling, or minor bruising resolving within 24-48 hours. Normal activities can be resumed shortly after treatment.

8. How Do Polynucleotides Improve Hair Growth?

Polynucleotide injections stimulate blood circulation, reduce scalp inflammation, and nourish hair follicles, making them an excellent non-surgical solution for hair thinning, scalp health improvement, and strengthening weak hair strands.

Expertise and Technology

Polynucleotide treatment is a cutting-edge, medically-backed procedure that requires a high level of expertise and advanced technology. Dr Chike Emeagi is dedicated to using the most advanced technology and personalized treatments to deliver the best results. We pride ourselves on our extensive training and commitment to excellence, ensuring that each treatment is performed with precision and care. By staying at the forefront of aesthetic treatments, we provide our clients with the most effective solutions for skin regeneration and rejuvenation.

Personalized Treatment Plans

At our clinic, we recognize that every individual has unique skin concerns and needs. That’s why we offer personalized treatment plans tailored to address specific issues such as fine lines and wrinkles, uneven skin texture and tone, dryness, lack of elasticity, and scars. During consultation, Dr Chike Emeagi will assess your skin and advise on the most appropriate products and treatments to meet your needs. By customizing each treatment plan, we ensure that you receive the best possible care and achieve the desired results for your skin health and appearance.

Why Choose Hampstead Aesthetics for Polynucleotide Treatment in London?

At Hampstead Aesthetics, we specialize in cutting-edge regenerative treatments, providing:

✅ Customized treatment plans for skin and hair restoration

✅ Expert care under Dr. Chike Emeagi MBBS, MRCGP, MRCS-Ed, MSc, MBA, a leading GMC-registered aesthetic doctor

✅ FDA-approved polynucleotide therapy for collagen stimulation and skin regeneration

✅ A professional, comfortable setting for optimal results

📌 Experience the next generation of regenerative aesthetics. Book your Polynucleotide Therapy consultation today at Hampstead Aesthetics!